Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor. Brand name: Refludan, Generic: Lepirudin rDNA for injection. Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. It differs by the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.

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dbpedia-owl:abstract
  • Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor. Brand name: Refludan, Generic: Lepirudin rDNA for injection. Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. It differs by the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63. Lepirudin may be used as an anticoagulant when heparins are contra-indicated because of heparin-induced thrombocytopenia.
  • Lepirudina é um fármaco que age como inibidor direto da trombina. Lepirudina pode ser utilizado como anticoagulante quando as heparinas (não fracionada ou de baixo peso molecular) são contra-indicadas por causa da trombocitopenia induzida por heparina.
  • La lépirudine ou r-hirudine est un anticoagulant mis au point par recombinaison génétique à partir de l'hirudine.
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  • 120993-53-5
dbpedia-owl:drugbank
  • BTD00024
dbpedia-owl:iupacName
  • [Leu1,Thr2]-63-desulfohirudin
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  • B01
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  • BTD00024
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  • Renal
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  • [Leu1,Thr2]-63-desulfohirudin
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  • D03692
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rdfs:comment
  • Lepirudina é um fármaco que age como inibidor direto da trombina. Lepirudina pode ser utilizado como anticoagulante quando as heparinas (não fracionada ou de baixo peso molecular) são contra-indicadas por causa da trombocitopenia induzida por heparina.
  • Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor. Brand name: Refludan, Generic: Lepirudin rDNA for injection. Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. It differs by the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.
  • La lépirudine ou r-hirudine est un anticoagulant mis au point par recombinaison génétique à partir de l'hirudine.
rdfs:label
  • Lépirudine
  • Lepirudin
  • Lepirudina
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